| Title | Leishmania DNA Replication Timing: A Stochastic Event? |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Rocha-Granados MC, Klingbeil MM |
| Journal | Trends Parasitol |
| Volume | 32 |
| Issue | 10 |
| Pagination | 755-757 |
| Date Published | 2016 10 |
| ISSN | 1471-5007 |
| Keywords | Animals, DNA Replication Timing, Drug Delivery Systems, Genomic Instability, Humans, Leishmania, Leishmaniasis, Replication Origin |
| Abstract | For eukaryotic genomes, DNA synthesis initiates at multiple discrete regions known as replication origins in a dynamic yet regulated manner to ensure genomic stability. Two recent studies using different approaches reveal few Leishmania origins and that origin firing may proceed in a mainly stochastic manner. |
| DOI | 10.1016/j.pt.2016.05.011 |
| Alternate Journal | Trends Parasitol. |
| PubMed ID | 27255527 |
| Grant List | R21 AI126455 / AI / NIAID NIH HHS / United States |
Department of Microbiology